N-alpha-(menthane carbonyl) amino acid amides and

专利名称：N-alpha-(menthane carbonyl) amino acid

amides and their use as physiologicalcoolants

发明人：LEY, JAKOB申请号：EP07117428.8申请日：20070927公开号：EP1913976A1公开日：20080423

摘要：1-Isopropyl-4-methyl-cyclohexane compounds (I) or their mixtures andstereoisomers (enantiomers or diastereomers), are new. 1-Isopropyl-4-methyl-cyclohexane compounds of formula (I) or their mixtures and their stereoisomers(enantiomers or diastereomers), are new. Either R 1>, R 2>H or cyclic, optionally

saturated, optionally one or more substituted 1-5C hydrocarbon; or R 1>R 2> connectedover a bond or by O, S or NH : 3-7-membered ring; either R 3>, R 4>H, cyclic, optionallysaturated 1-10C-hydrocarbon or 1-10C-hydrocarbon substituted by R 5>X; or R 3>R 4>connected over a bond or -O-, -S or -NH- : 3-7-membered heterocyclic ring; X : O, S or -NR6>; and R 5>, R 6>H or cyclic, optionally saturated 1-5C-hydrocarbon. Independentclaims are included for: (1) a mixture comprising (I) or its mixture, one or more furthermaterials with physiological cooling effect, and optionally causing flavorful effect, one ormore aroma materials without physiological cooling effect and/or one or moretrigeminal or mouthwash effective materials without physiological cooling effect; (2) atherapeutic or non-therapeutic procedure for obtaining a physiological cooling effect onthe skin and/or mucous membrane comprising applying (I), mixture or preparation on the

skin and/or mucous membrane; and (3) the preparation of (I). [Image].

申请人：SYMRISE GMBH & CO. KG

地址：Mühlenfeldstrasse 1 37603 Holzminden DE

国籍：DE

代理机构：Eisenführ, Speiser & Partner

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