Nitrosated and nitrosylated steroids compositions,

专利名称：Nitrosated and nitrosylated steroids

compositions, and methods for treatingrespiratory disorders

发明人：David S. Garvey,L. Gordon Letts,H. Burt

Renfroe,Stewart K. Richardson

申请号：US09157242申请日：19980918公开号：US06197762B1公开日：20010306

摘要：Disclosed are (i) compounds of a steroid, a &bgr;-agonist, an anticholinergic, amast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linkedto a NO or NOgroup or a group which stimulates endogenous production of NO or EDRFin vivo; (ii) compositions of steroids, &bgr;-agonists, anticholinergics, mast cell stabilizersand PDE inhibitors, which can optionally be substituted with at least one NO or NOmoietyor a group which stimulates endogenous production of NO or EDRF in vivo, and acompound that donates, transfers or releases nitric oxide as a charged species, i.e.,nitrosonium (NO) or nitroxyl (NO), or as the neutral species, nitric oxide (NO•) or thatstimulates endogenous production of NO or EDRF in vivo; and (iii) uses for them inpreventing and/or treating respiratory disorders.

申请人：NITROMED, INC.

代理机构：Hale and Dorr LLP

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