Immunogenic complex, a method for producing the sa

专利名称：Immunogenic complex, a method for

producing the same, and the use thereof asan immune stimulant, vaccines and reagents

发明人：Morein, Bror申请号：EP85850326.1申请日：19851016公开号：EP0180564B1公开日：19910717

摘要：The invention relates to a process for preparing an immunogenic complexcomprising a carrier molecule prepared by mixing viruses, mycoplasmas, bacterias, animalcells or proteins or peptides having hydrophobic regions with one or more solubilizingagents, whereby a complex having been formed between proteins or peptides andsolubilizing agents, whereafter the proteins or the peptides have been separated fromthe solubilizing agent in the presence of a glycoside solution which contains one or moreglycosides having hydrophobic and hydrophilic regions in a concentration of at least thecritical micellular concentration, or alternatively have been separated from the

solubilizing agent and transferred directly to the aforementioned glycoside solution, andthe carrier molecule being bound to one or more molecules selected from peptides,proteins, carbohydrates, lipoproteins, glycolipides or small molecules, such as biotine, bycoupling with known methods between functional coupling groups in the boundmolecules and functional groups in the peptides or the proteins in the carrier molecule.…The invention also relates to a method for preparing such immunogenic complexes,compositions, vaccines containing such complexes and to reagents.

申请人：MOREIN, BROR

地址：OLLONSTIGEN 3 VRETA; S-75590 UPPSALA

代理机构：Fagerlin, Heléne

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