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N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzene

2021-07-10 来源:客趣旅游网
专利内容由知识产权出版社提供

专利名称:N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and theirtherapeutic use

发明人:Lisa Patel,Stephen Allan Smith,Iain Robert

Greig,Samuel Cameron Williams

申请号:US15484256申请日:20170411公开号:US09796670B2公开日:20171024

摘要:The present invention pertains generally to the field of therapeutic compounds.More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to hereinas HMC compounds) that are useful, for example, in the treatment of disorders (e.g.,diseases) including, inflammation and/or joint destruction and/or bone loss; disordersmediated by excessive and/or inappropriate and/or prolonged activation of the immunesystem; inflammatory and autoimmune disorders, for example, rheumatoid arthritis;psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (COPD); asthma;atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis;systemic lupus erythematosus; Sjogren's syndrome; a disorder associated with bone loss,such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis,

osteoporosis, cancer-associated bone disease, or Paget's disease; cancer, such as ahaematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solidtumor cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer,renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer,prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, ormelanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma;or a rare vasculitide, such as Behçet's disease. The present invention also pertains topharmaceutical compositions comprising such compounds, and the use of suchcompounds and compositions, for example, in therapy.

申请人:PIMCO 2664 LIMITED

地址:London GB

国籍:GB

代理机构:Swanson & Bratschun, L.L.C.

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