专利名称：NITROSATED AND NITROSYLATED
NEBIVOLOL AND ITS METABOLITES,COMPOSITIONS AND METHODS OF USE
发明人：GARVEY, David, S.申请号：EP02766876.3申请日：20020501公开号：EP1406608A2公开日：20040414
摘要：The invention describes novel nitrosated and/or nitrosylated nebivolol, novelnitrosated and/or nitrosylated metabolites of nebivolol and novel compositionscomprising at least one nitrosated and/or nitrosylated nebivolol and/or at least onenitrosated and/or nitrosylated metabolite of nebivolol, and optionally, at least one nitricoxide donor and/or at least one antioxidant or a pharmaceutically acceptable saltthereof, and/or at least one compound used to treat cardiovascular disease or a
pharmaceutically acceptable salt thereof, and/or at least one nitrosated compound usedto treat cardiovascular diseases. The invention also provides novel compositionscomprising nebivolol and/or at least one metabolite of nebivolol and at least one nitricoxide donor, and, optionally, at least one antioxidant or a pharmaceutically acceptablesalt thereof, and/or at least one compound used to treat cardiovascular diseases or apharmaceutically acceptable salt thereof, and/or at least one nitrosated compound usedto treat cardiovascular diseases. The compounds and compositions of the invention canalso be bound to a matrix. The nitric oxide donor is a compound that donates, transfersor releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing
factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxidesynthase and may preferably be isosorbide dinitrate and/or isosorbide mononitrate. Theantioxidant may preferably be a hydralazine compound or a pharmaceutically acceptablesalt thereof. The invention also provides methods for treating and/or preventing vasculardiseases characterized by nitric oxide insufficiency; and for treating and/or preventingRaynaud's syndrome; and for treating and/or preventing cardiovascular diseases ordisorders.
申请人：Nitromed, Inc.
地址：12 Oak Park Drive Bedford, MA 01730 US
国籍：US
代理机构：Wright, Robert Gordon McRae
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