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IMPROVED SYNTHESIS OF SULFURIZED OLIGONUCLEOTIDES

2020-06-08 来源:客趣旅游网
专利内容由知识产权出版社提供

专利名称:IMPROVED SYNTHESIS OF SULFURIZED

OLIGONUCLEOTIDES

发明人:COLE, Douglas, L.,RAVIKUMAR, Vasulinga,

T.,CHERUVALLATH, Zacharia, S.

申请号:EP98953408.6申请日:19981013公开号:EP1023310A1公开日:20000802

摘要:Methods for the formation of sulfurized oligonucleotides are provided. Themethods allow for the formation of phosphorothioate linkages in the oligonucleotides orderivatives, without the need for complex solvent mixtures and repeated washing orsolvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotidescan be sulfurized according to the methods of the invention with higher yields than havebeen previously reported.

申请人:ISIS PHARMACEUTICALS, INC.

地址:2292 Faraday Avenue Carlsbad, CA 92008 US

国籍:US

代理机构:Hallybone, Huw George

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